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- W2370366906 abstract "Objective To study the effect of HES130/0.4 on early lung injury induced by shock and resuscitation from hemorrhagic shock in rats by measuring the changes of SOD, MDA, MPO, and observing the changes of lung tissue structure. Method The 54 healthy male rats (weighting 250-280 g) were randomly divided into three groups: 1) control group (group C); 2) Ringer lactate solution group (group RL); 3) 6%HES130/0.4 group (group HES). Hemorrhagic shock model was performed according to Wiggers’ modified method. The changes of SOD, MDA, MPO in lung were measured at 1, 2, 4 h after resuscitation. After the samples were stained, the histological features of lung tissue were examined through light microscope. Result 1) After resuscitation, MDA content increased gradually in group RL and in group HES. At the same time points, MDA in group HES was lower than that in group RL (P0.01) but higher than that in group C (P0.01). After resuscitation, SOD content decreased gradually in group RL and in group HES. At the same time points, SOD in group HES was higher than that in group RL(P0.01) but lower than that in group C(P0.01). 2) At the same time points, MPO in group HES was lower than that in group RL (P0.01) but higher than that in group C (P0.01). 3) Lung tissue edema and neutrophil accumulation could be observed through microscope in group RL and group HES, but the changes in the later were be mollified. Conclusion Resuscitation with HES130/0.4 could alleviate early lung injury induced by hemorrhagic shock and resuscitation in rats." @default.
- W2370366906 created "2016-06-24" @default.
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- W2370366906 date "2010-01-01" @default.
- W2370366906 modified "2023-09-23" @default.
- W2370366906 title "Effect of HES130/0.4 reducing early lung injury in rats after resuscitation from hemorrhagic shock" @default.
- W2370366906 hasPublicationYear "2010" @default.
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