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- W2370392337 abstract "ObjectiveTo investigate the expressions of Bmi-1 and hTERT protein in gastric carcinoma,and explore their relation with clinical pathology.MethodsThe expressions of Bmi-1 and hTERT protein were detected,by PV-9000 immunohistochemical method,in specimens of 70 gastric carcinoma,20 chronic atrophic gastritis and 10 paraneoplastic normal gastric mucous membrane.ResultsThe positive expressive rates of Bmi-1 and hTERT in cancer were 71.4% and 78.6%,respectively,which were higher than that in normal tissue(0 and 0,respectively),and that in chronic atrophic gastritis(20.0% and 15.0%,respectively),all the differences were significant(χ2=17.14-27.44,P0.01).The positive expressions of Bmi-1 and hTERT were closely correlated with the depth of cancer tissue infiltration,clinical stage and lymph node metastasis(χ2=6.375-26.480,P0.05),and not with gender,Borrmann classification and differentiation(χ2=0.047-1.052,P0.05).The expression of Bmi-1 in gastric cancer was positively correlated with hTERT(r=0.826,P0.01).ConclusionThe expressions of Bmi-1 and hTERT protein are closely related with the occurrence,development,invasion and metastasis of gastric cancer,which can be used as an important reference for early diagnosis,metastasis judgment and prognostic prediction of this malignancy." @default.
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- W2370392337 date "2011-01-01" @default.
- W2370392337 modified "2023-09-25" @default.
- W2370392337 title "EXPRESSIONS OF Bmi-1 AND hTERT PROTEIN IN GASTRIC CARCINOMA" @default.
- W2370392337 hasPublicationYear "2011" @default.
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