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- W2370395075 abstract "Objective To explore the hepatic regeneration of cirrhotic rats following induced pluripotent stem cells transplantation after partial hepatic resection.Methods Cirrhosis was induced in rats by hypodermic injection of CCl4.36 male cirrhotic rats were randomized into two groups of eighteen rats each: in each group,30% of the hepatic was resected after partial hepatectomy,group A were injected with normal saline via portal vein,and group B were injected with induced pluripotent stem cells.The level of serous ALT and AST were tested before operation and at 12h,24h,3d,7d,and14d after hepatectomy in each group,Liver regeneration rate of liver were examined at 3d,7d,and14d after hepatectomy;and pathological sections of liver were observed,Frozen sections of groupB were observed under fluorescence.Results There was no statistical difference of liver regeneration rate at various time points respectively between the two groups(P0.05).The level of aminotransferase in serum in groupA was significantly higher compared with groupB at 7d and14d after hepatectomy respectively(P0.05).Conclusion Liver function of cirrhotic rats can be improved with the induced pluripotent stem cells transplantated after partial hepatic resection." @default.
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- W2370395075 date "2012-01-01" @default.
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- W2370395075 title "Effect of induced pluripotent stem cells transplantation on cirrhotic rats after acute liver injury" @default.
- W2370395075 hasPublicationYear "2012" @default.
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