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- W2370454383 abstract "OBJECTIVE To evaluate the clinical significance of the introduction of cefepime breakpoint for Enterobacteriaceae into the description of susceptible-dose dependence(SDD)in CLSI M100-S24.METHODS The Phoenix WinNonlin 5.2and the Matlab software were used to simulate the pharmacokinetic curves and calculate TMIC% of cefepime under different dosing regimens respectively.The clinical microbiology data were also reviewed to further evaluate the clinical significance of the introduction of cefepime breakpoint for Enterobacteriaceaeinto description of SDD.RESULTS Pharmacokinetic curves showed different dosing regimens had different Cmax and TMIC%.Increase of the single dose significantly elevated Cmax.At the single dose of 1g and 2g,Cmax was 75μg/ml and 150μg/ml respectively,(plasma concentration was8μg/ml for 64.68% of treatment duration in the 1g/12 hregimen and was8μg/ml for 81.65%of treatment duration in the 2g/12 hregimen.Shorter dosing interval significantly increased T MIC%.The 1 q/6 h dosing regimen kept the plasma concentration higher than 8μg/ml throughout the treatment duration.CONCLUSIONIntroduction of cefepime breakpoint for Enterobacteriaceaeinto description of SDD will help physicians to use cefepime more properly." @default.
- W2370454383 created "2016-06-24" @default.
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- W2370454383 date "2014-01-01" @default.
- W2370454383 modified "2023-09-23" @default.
- W2370454383 title "Evaluation on the clinical significance of introduction of cefepime breakpoint for Enterobacteriaceaeinto description of susceptible-dose dependence" @default.
- W2370454383 hasPublicationYear "2014" @default.
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