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- W2370457788 abstract "Objective To investigate the apoptosis of vascular smooth muscle cells (VSMCs) of rats induced by oxidized low-density lipoprotein (Ox-LDL) and explore its molecular mechanism. Method Electron microscopy, Hoechst 33342 staining assay and Western blotting were performed to study Ox-LDL-induced apoptosis in rat VSMCs. Results VSMCs treated with Ox-LDL for 24 h showed typical apoptotic changes: cell shrinkage, cytoplasm and chromatin condensation, observed electromicroscopically. Hoechest 33342 staining assay showed thick granulated fluorescence in condensed nuclei and cytoplasm, and apoptotic bodies was also visible. Western blotting demonstrated that p53 protein level increased and Bcl-2 protein level decreased when apoptosis occurred. Conclusions Ox-LDL can induce apoptosis in VSMCs in dose- and concentration-dependent manner. The expression of p53, acting to induce apoptosis, was increased, while that of Bcl-2, inhibitor of apoptosis,was decreased and altered expressions of p53 and bcl-2 gene possibly play an important role in regulating Ox-LDL-induced apoptosis." @default.
- W2370457788 created "2016-06-24" @default.
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- W2370457788 date "2000-01-01" @default.
- W2370457788 modified "2023-09-24" @default.
- W2370457788 title "Induction of apoptosis in vascular smooth muscle cells by oxidized low-density lipoprotein and its molecular mechanism" @default.
- W2370457788 hasPublicationYear "2000" @default.
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