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- W2370458082 abstract "Objective To investigate the effect of atorvastatin on the activity of MPO and the infarct size in acute myocardial infarction of rats. Methods AMI model was established by ligation of anterior descending branch of left coronary artery in male SD rats.Fifty-six SD rats were randomly divided into three groups; therapeutic, control and sham operation groups.The therapeutic group was pretreated with atorvastatin 10 mg·kg-1·d-1,the control group and sham operation group were pretreated with saline. Myocardial infarct size was assessed by TTC staining,and PMN were studied by HE staining and the number of the infiltrating PMN was measured by light microscopy.The MPO activity of the serum and the myocardium was measured by colorimetric method. Results The number of PMN increased significantly in the control group and therapeutic group compared with the sham-operation group(P0.01),but was decreased significantly in the therapeutic group as compared with the control group (P0.01). The activity of MPO was increased significantly in the control group and therapeutic group compared with the sham-operation group (P0.01), but was decreased significantly in the therapeutic group as compared with control group (P0.01). The infarct size in the therapeutic group was significantly smaller than that in the control group (P0.01). Conclusion Acute myocardial infarction can increase the infiltration of PMN and the activity of MPO. Short-term (3days)atorvastatin treatment can significantly inhibit such changes,thus relieve AMI injury in rats and reduce myocardial infarct size, strongly suggesting that atorvastatin has protective effect on myocardium." @default.
- W2370458082 created "2016-06-24" @default.
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- W2370458082 date "2007-01-01" @default.
- W2370458082 modified "2023-09-23" @default.
- W2370458082 title "Effect of atorvastatin on the activity of MPO in acute myocardial infarction of rats" @default.
- W2370458082 hasPublicationYear "2007" @default.
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