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- W2370466573 abstract "Aim To explore the effect of tacrolimus(FK506) on cardiac hypertrophy and TLR4 signaling pathway in myocardium.Methods Thirty male Wistar rats were randomly divided into three groups: sham-operation group(S group),model group(M group),and FK506 group(F group).Model rats underwent constriction of abdominal aorta(AAC).Rats from F group were conditioned with FK506(0.5 mg·kg-1 body weight every day)from three days before AAC to four weeks after AAC by intramuscular injection.After transthoracic echocardiographic analysis,hearts were stored at-80℃ for real-time quantitative PCR,Western blot,immunofluorescence,and enzyme-linked immunoadsordent assay(ELISA).Results Both the size of heart and cardiomyocyte and the level of ANP,calcineurin(CaN) mRNA and TLR4 signaling molecules were increased(P0.01;P0.05) in M group,compared with S group.FK506 lowered heart and the cardiomyocytes size(P0.05),and inhibited expression of ANP,CaN and TLR4 signaling molecules significantly.Conclusion CaN plays an important role in the progress of cardiac hypertrophy.FK506 may inhibit AAC-induced cardiac hypertrophy by CaN and TLR4 signal systems." @default.
- W2370466573 created "2016-06-24" @default.
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- W2370466573 date "2013-01-01" @default.
- W2370466573 modified "2023-09-26" @default.
- W2370466573 title "Effects of tacrolimus on cardiac hypertrophy and toll like receoptor 4 signaling pathway in myocardium" @default.
- W2370466573 hasPublicationYear "2013" @default.
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