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- W2370470894 abstract "Cryopyrin-associated periodic syndromes(CAPS) is a spectrum of rare inherited inflammatory diseases,including familial cold autoinflammatory syndrome(FCAS) and Muckle-Wells syndrome(MWS).Symptoms of the disorders include inflammatory reations such as fever,chills,rash,fatigue,joint pain,and eye redness.The proinflammatory cytokine interleukin-1(IL-1) has been implicated as a pathogenic factor in the disease.Thus,neutralization of IL-1 activity has emerged as an important therapeutic strategy to alleviate the symptoms of CAPS.The U.S.Food and Drug Administration has approved rilonacept,an interleukin-1 blocker,to treat the rare inflammatory diseases.Rilonacept can blind to IL-1b and IL-1a with high affinity and potently inhibit IL-1 activity.This article briefly reviewed the recent progress in clinical application of rilonacept." @default.
- W2370470894 created "2016-06-24" @default.
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- W2370470894 date "2009-01-01" @default.
- W2370470894 modified "2023-09-27" @default.
- W2370470894 title "Progress in the research of the interleukin-1 blocker rilonacept" @default.
- W2370470894 hasPublicationYear "2009" @default.
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