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- W2370484927 abstract "【Objective】To investigate the risk factors for antibiotic associated diarrhea(AAD) in elderly patients.【Methods】From Jan 2008 to Jan 2009,hospitalized patients(60 y) with antibiotics for more than 1 week were enrolled.Clinical features [eg.age,gender,complications,serum albumin and creatinine,proton pump inhibitor(PPI),antibiotics and diarrhea] were analyzed by bivariate Logistic regression analysis.【Results】Of 181 patients,the incidence of AAD was 21.5 %;mean age in AAD group(n =39,male 27,female 12) and in non-AAD(n =142,male 114,female 28) was(80.7±7.34) y vs(77.8±7.62) y,P 0.05.The incidence rank of AAD caused by one kind of antibiotic was the third generation cephalosporin/carbopenems(28.8 %),broad-spectrum penicillins(18.2 %),fluoroquinolones(8.7 %),cephamycin(8.3 %),respectively.The incidence of AAD was higher with combined antibiotic therapy than with monotherapy(44.8 % vs 17.1 %,P 0.05).The independent risk factors for AAD included hypoalbuminemia,high creatinine,antibiotics combination and application of PPI(OR 0.879,1.006,3.994 and 8.732),respectively.Age,gender and complications did not influence the onset of AAD.【Conclusion】It is important to notice elderly patients' self-status(eg.serum albumin and creatinine),antibiotics combination and PPI application to early recognize high risks for AAD." @default.
- W2370484927 created "2016-06-24" @default.
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- W2370484927 date "2010-01-01" @default.
- W2370484927 modified "2023-09-25" @default.
- W2370484927 title "Risk factors for antibiotic associated diarrhea in elderly patients" @default.
- W2370484927 hasPublicationYear "2010" @default.
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