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- W2370485514 abstract "To investigate the effects of Ang-(1-7) and AngⅡ on potassium channels in guinea pig myocytes. Potassium currents were recorded with patch electrodes in a whole-cell clamp configuration. Results:Ang-(1-7) 2μmol/L increased the amplitude of I_k from 13.53±0.92pA/pF to 17.58±2.73pA/pF( P 0.05). However,AngⅡ 2μmol/L decreased the amplitude of I_k from 13.94±1.49pA/pF to 8.96±2.46pA/pF( P 0.01). The effects of Ang-(1-7) or AngⅡ on I_k could be almost completely eliminated by Sarthran,but Valsartan could not. The amplitude of I_ K1 was not affected by Ang-(1-7) 2μmol/L( P 0.05) ,but was increased by AngⅡ 2μmol/L from -38.67±8.24pA/pF to -53.47±7.48pA/pF( P 0.01). Sarthran eliminated the effect of AngⅡ on I_ K1 ,but Valsarthan did not. Conclusions: Ang-(1-7) increases the amplitude of I_k through non specific AT_1 receptor. AngⅡ decreases the amplitude of I_k through specific AT_1 receptor. I_ K1 is increased by AngⅡ through non specific AT receptor." @default.
- W2370485514 created "2016-06-24" @default.
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- W2370485514 date "2004-01-01" @default.
- W2370485514 modified "2023-09-24" @default.
- W2370485514 title "The Effects of Angiotensin-(1-7) and Angiotensin II on Potassium Channels in Guinea Pig Myocytes" @default.
- W2370485514 hasPublicationYear "2004" @default.
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