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- W2370486102 abstract "Objective:High performance liquid chromatography method was established to determine the related substances and the degradation substances in clemastine fumarate ant its tablets.Methods:An ODS-3 C18 column(250 mm×4.6 mm,5 μm)with UV detection at 210 nm,and acetonitrile-sodium octanesulfonate solution(50∶ 50) as the mobile phase were used in HPLC.The flow rate was 1.0 mL·min-1,and the temperature of the column was 35 ℃.Results:An excellent separation was achieved for clemastine fumarate,excipient and its related substances.The reproducibility and precision of the method were good(RSD0.3%).Conclusion:This method was accurate,simple,quick and effective for determination of related substances and the degradation substances in clemastine fumarate tablets.It was also suitable for the quality control for clemastine fumarate and its tablets." @default.
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- W2370486102 date "2011-01-01" @default.
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- W2370486102 title "HPLC determination of related substances in clemastine fumarate and its tablets" @default.
- W2370486102 hasPublicationYear "2011" @default.
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