FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2370491159> ?p ?o ?g. }

• W2370491159 abstract "Objective Airway inflammation is considered to be the cause of asthma. The inflammatory component of asthma is usually assessed indirectly by symptoms and spirometry, which may often be inaccurate. The introduction of induced sputum noninvasively makes it possible to examine the inflammatory components. The examination of sputum cell counts can now be a direct and reliable method to measure indices of airway inflammation. The aim of this study was to evaluate the clinical application of the detection of sputum inflammatory cells reflecting the state of airway inflammation in asthmatic children. Methods Sputum was collected from 105 children with asthma attending the respiratory clinic and in the ward at Beijing Children′s Hospital. The children aged 4 to 14 years, the average age was 8.8 years; 70 of them were male and 35 were female. The causes of asthma attack were divided into 2 group: respiratory infection (n=30, 28.6%) and non-respiratory infection (n=75, 71.4%). The application of inhaled corticosteroids therapy was divided into 3 group: non-preventing therapy (n=73, 69.5%), background asthma therapy (n=12, 11.4%) or irregular inhaled preventing (n=20, 19.1%). The asthma attacks had 3 inflammatory cell patterns: eosinophilic (n=48, 45.7%), combined eosinophilic/neutrophilic (E/N; n=18, 17.1%) or noneosinophilic (n=39, 37.1%). Sputum samples were obtained by spontaneous expectoration or by hypertonic saline aerosol induction. Sputum smear was stained with May-Grunwald′s plus Gimsa and Papanicolaou′s methods. Differential inflammatory cells counts were performed by counting 500 cells under the light microscope, while patients were tested for allergy by skin print test and pulmonary function. Results The percentage of eosinophils in sputum of asthmatic children with respiratory infection was significantly lower than that without respiratory infection (median 4% vs 13%, P=0.001). Contrarily, the percentage of neutrophils in sputum of children with cause of respiratory tract infection was significantly higher compared with asthmatic children of non-infection cause (median 74% vs 30%, P=0.001). Sputum eosinophils in patients with inhaled corticosteroids as background asthma therapy (median 1%) was significantly different from sputum eosinophils in patients with irregular inhaled preventer (median 15%, P=0.009) or non-preventing therapy (median 7%, P=0.03). Twelve of 18 (67%) patients in the mixed E/N group had moderate and severe asthma attacks, and had a lower forced expiratory volume in one second (FEV 1)% predicted than that in eosinophilic group or noneosinophilic group (mean 66.09% vs 84.16% or 84.90%, P0.05). Conclusion Sputum inflammatory cells may be a useful marker reflecting the state of airway inflammation in assessment of the therapeutic efficacy." @default.
• W2370491159 created "2016-06-24" @default.
• W2370491159 creator A5024643453 @default.
• W2370491159 date "2001-01-01" @default.
• W2370491159 modified "2023-09-23" @default.
• W2370491159 title "The relationship between sputum inflammatory cells and asthma state in children" @default.
• W2370491159 hasPublicationYear "2001" @default.
• W2370491159 type Work @default.
• W2370491159 sameAs 2370491159 @default.
• W2370491159 citedByCount "0" @default.
• W2370491159 crossrefType "journal-article" @default.
• W2370491159 hasAuthorship W2370491159A5024643453 @default.
• W2370491159 hasConcept C126322002 @default.
• W2370491159 hasConcept C142724271 @default.
• W2370491159 hasConcept C203014093 @default.
• W2370491159 hasConcept C2776042228 @default.
• W2370491159 hasConcept C2776301714 @default.
• W2370491159 hasConcept C2779758542 @default.
• W2370491159 hasConcept C2780333948 @default.
• W2370491159 hasConcept C2781069245 @default.
• W2370491159 hasConcept C3017567848 @default.
• W2370491159 hasConcept C71924100 @default.
• W2370491159 hasConcept C90924648 @default.
• W2370491159 hasConceptScore W2370491159C126322002 @default.
• W2370491159 hasConceptScore W2370491159C142724271 @default.
• W2370491159 hasConceptScore W2370491159C203014093 @default.
• W2370491159 hasConceptScore W2370491159C2776042228 @default.
• W2370491159 hasConceptScore W2370491159C2776301714 @default.
• W2370491159 hasConceptScore W2370491159C2779758542 @default.
• W2370491159 hasConceptScore W2370491159C2780333948 @default.
• W2370491159 hasConceptScore W2370491159C2781069245 @default.
• W2370491159 hasConceptScore W2370491159C3017567848 @default.
• W2370491159 hasConceptScore W2370491159C71924100 @default.
• W2370491159 hasConceptScore W2370491159C90924648 @default.
• W2370491159 hasLocation W23704911591 @default.
• W2370491159 hasOpenAccess W2370491159 @default.
• W2370491159 hasPrimaryLocation W23704911591 @default.
• W2370491159 hasRelatedWork W1750369209 @default.
• W2370491159 hasRelatedWork W1986203636 @default.
• W2370491159 hasRelatedWork W1992347215 @default.
• W2370491159 hasRelatedWork W1997023172 @default.
• W2370491159 hasRelatedWork W2020370294 @default.
• W2370491159 hasRelatedWork W2084177838 @default.
• W2370491159 hasRelatedWork W2098997466 @default.
• W2370491159 hasRelatedWork W2119011086 @default.
• W2370491159 hasRelatedWork W2121892537 @default.
• W2370491159 hasRelatedWork W2159638894 @default.
• W2370491159 hasRelatedWork W224419381 @default.
• W2370491159 hasRelatedWork W2359869487 @default.
• W2370491159 hasRelatedWork W2404283239 @default.
• W2370491159 hasRelatedWork W2405947756 @default.
• W2370491159 hasRelatedWork W2774178399 @default.
• W2370491159 hasRelatedWork W2990215157 @default.
• W2370491159 hasRelatedWork W3024635961 @default.
• W2370491159 hasRelatedWork W3028860933 @default.
• W2370491159 hasRelatedWork W3145727710 @default.
• W2370491159 hasRelatedWork W1954005706 @default.
• W2370491159 isParatext "false" @default.
• W2370491159 isRetracted "false" @default.
• W2370491159 magId "2370491159" @default.
• W2370491159 workType "article" @default.