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- W2370492034 abstract "Objective To investigate the effect of human sodium/iodide symporter(hNIS) gene under human telomerase reverse transcriptase(hTERT) promoter on the radioiodine uptake by glioma cells.Methods The recombinant adenovirus expressing hNIS gene under hTERT promoter was used to transfect the U87 and U251 malignant glioma cell lines.The radioiodine uptake by the cells was detected using γ-counter.Results The iodide uptake by Ad-hTERT-hNIS transfected cells was about 30-40 times higher than that by the control cells.Conclusion It is demonstrated that the tumor-specific iodide uptake has been achieved by the hTERT promoter-directed hNIS expression in malignant glioma cell lines." @default.
- W2370492034 created "2016-06-24" @default.
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- W2370492034 date "2011-01-01" @default.
- W2370492034 modified "2023-09-23" @default.
- W2370492034 title "Increased uptake of radioiodine by glioma cells transfected with human sodium/iodide symporter gene under targeting promoter" @default.
- W2370492034 hasPublicationYear "2011" @default.
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