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- W2370494611 abstract "Objectives Compare the effects of intravenous route and peritoneal route on target uptake and gene expression of liver delivered by liposomes. Methods After encapsulated by lipofectamine, the plasmid expressed in euksryotic cells was transferred into rat's body by intravenous and intraperitoneal injections respectively, then observed the result at varying durations by in situ hybridization and immunohistochemistry. Results The expression of the plasmid encapsulated by liposomes was obvious after transferred in vivo through intravenous route and intraperitoneal route 24 hours, and one week later afterwards, the expression began to decrease, but still could be found three weeks later.Both intravenous route and intraperitoneal route made the liver as the major distribution and expression tissue of the plasmid, but the distribution and expression of the plasmid transferred through intravenous route was higher in liver than that transferred through intraperitoneal route. Conclusion The effects of intravenous route on liver target uptake and expression of the plasmid encapsulated by liposomes is better than that of intra peritoneal route." @default.
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- W2370494611 date "1999-01-01" @default.
- W2370494611 modified "2023-09-23" @default.
- W2370494611 title "Comparative studies of intravenous route and peritoneal route in target uptake and gene expression of liver delivered by liposomes" @default.
- W2370494611 hasPublicationYear "1999" @default.
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