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- W2370504885 abstract "Objective To explore the effects of curcumin on the proliferation and apoptosis of human renal cell carcinoma cell line ACHN in vitro,and to investigate its mechanisms.Methods The human renal cell carcinoma cell line ACHN was treated with curcumin of different concentrations for 24h respectively.The MTT assay was used to evaluate the cytotoxic effects of curcumin on ACHN cells.The flow cytometry were utilized to observe and detect the apoptosis of ACHN cells induced by curcumin.The expression of Bcl-2,Bax and NF-кP65 mRNA were evaluated by Reverse Transcription-Polymerase Chain Reaction(RT-PCR) method.The expression of Bcl-2,Bax,NF-κBP65 and IκB were evaluated by Western blot method.Results The curcumin of different concentrations could significantly inhibit the proliferation and induce apoptosis of ACHN cells,with obvious dose-and time-dependent effects.With intervention of different concentrations of curcumin for 24h,the expression of Bcl-2 and NF-κBP65 mRNA in ACHN cells was decreased while the expression of Bax mRNA was increased(P0.05).BcI-2 and NF-κBP65 protein decreased,while Bax and IκB protein increased,as compared with those in the untreated group(P0.05).Conclusion The proliferation-inhibiting effects of curcumin on human renal cell carcinoma cell line ACHN may be related to up-regulating IκB and down-regulating NF-κB,which regulate the expression of the apoptosis genes Bcl-2/Bax and promote the apoptosis." @default.
- W2370504885 created "2016-06-24" @default.
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- W2370504885 date "2010-01-01" @default.
- W2370504885 modified "2023-09-23" @default.
- W2370504885 title "Effects of curcumin on the proliferation and apoptosis of human renal cell carcinoma cell line ACHN" @default.
- W2370504885 hasPublicationYear "2010" @default.
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