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- W2370506487 abstract "Objective To investigate the expression of endothelial cell specific molecule-1 (ESM-1), integrin β1 in tissues from salivary adenoid cystic carcinoma (SACC) and their clinical pathologic significances. Methods The expressions of ESM-1, integrin β1 were examined by immunohistochemistry and in situ hybridization respectively in 52 cases of SACC and in 11 normal salivary gland tissues adjacent to neoplastic lesions on a tissue microarray platform. And the relationship of their expressions was analyzed. Results 1) The expression of ESM-1 in SACC was significantly higher than that in normal salivary gland tissues (P0.01). 2) The expression of integrin β1 in SACC was significantly higher than that in normal salivary gland tissues (P0.01), and positively correlated to lymph node metastasis and nerve fiber encroachment. 3) The mRNA expression of ESM-1 was positively correlated to that of integrin β1 in SACC (r=0.372, P0.01). Conclusion 1) The expression of ESM-1 was up-regulated in SACC. 2) ESM-1 and integrin β1 might cooperate with each other to take roles in the carcinogenesis and development of SACC." @default.
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- W2370506487 date "2007-01-01" @default.
- W2370506487 modified "2023-09-24" @default.
- W2370506487 title "Expression of Endothelial Cell Specific Molecule-1 and Integrin β_1 in Salivary Adenoid Cystic Carcinoma and Their Significance" @default.
- W2370506487 hasPublicationYear "2007" @default.
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