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- W2370508715 abstract "Objective To investigate the effect of PA-MSHA vaccine on the apoptosis and proliferation of human breast cancer cells MCF-7 cultured in vitro and to discuss the possible mechanism.Methods After MCF-7 was treated with different concentrations of PA-MSHA vaccine for different time,MTT colorimetric assay was applied to examine the growth inhibition and the growing curves were drawn.Then,the apoptotsis rate and the change of cell cycle of breast cancer cells were detected by flow cytometry.The apoptotic features was observed with fluorescence microscope after stained by Hoechst 33258.Results PA-MSHA vaccine could inhibit the proliferation of MCF-7 cells in a time and dose-dependent manner.The flow cytometric analysis of the cell cycle distribution revealed that the tumor cell apoptotsis rate in the PA-MSHA vaccine group was significantly higher than that in the control group(P0.01),and the fraction of S phase cells decreased,while the fraction of G0/G1 phase cells increased compared with that in the control group(P 0.05).The significant apoptotic picture was obtained with fluorescence microscope.Conclusion PA-MSHA vaccine can cause tumor cell apoptosis,inhibit the growth proliferation in MCF-7 cells,and arrest them at G1 phase.Apoptosis induction may be the important mechanism for anti-tumor action of PA-MSHA vaccine." @default.
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- W2370508715 date "2010-01-01" @default.
- W2370508715 modified "2023-09-26" @default.
- W2370508715 title "Effect of pseudomonas aeruginosa vaccine on cell apoptosis and proliferation in human breast cancer cell line MCF-7" @default.
- W2370508715 hasPublicationYear "2010" @default.
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