Matches in SemOpenAlex for { <https://semopenalex.org/work/W2370516268> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2370516268 abstract "Objective:To develop a rapid HPLC method for the simultaneous quantification of albendazole(ABZ) and its metabolite,albendazole sulphoxide(ABZSX),in rat plasma.Methods: Plasma samples were extracted with ethyl acetate under alkaline conditions.Separation was achieved on a C18 reversed-phase analytical column at 35℃ with UV detection at 292nm.A gradient separation was applied according to the difference in the hydrophobicities of ABZ and its metabolites.The mobile phase consisted of a mixture of methanol-acetonitrile(1∶1) and 0.05% formic acid.The proportion of organic modifier was increased from 30% to 70% in 28min,then from 70% to 30% in 30min.Mobile phase flow rate was 1.0mL·min-1.Results: The assay was linear for concentration ranges of 0.025~1.992mg·L-1 for ABZ and 0.025~16.208mg·L-1 for ABZSX in rat plasma.The mean extraction recoveries of ABZ and ABZSX were 96.94% and 99.71%;their mean recoveries were 100.42% and 102.66%,respectively.The within-day and day-to-day coefficients of variation of ABZ and ABZSX were less than 8%.Conclusion: The method developed in this study can be applied to determine the plasma levels of ABZSX and ABZ in pharmacokinetic studies." @default.
- W2370516268 created "2016-06-24" @default.
- W2370516268 creator A5000266451 @default.
- W2370516268 date "2009-01-01" @default.
- W2370516268 modified "2023-09-23" @default.
- W2370516268 title "Determination of albendazole and its metabolite by HPLC in rats" @default.
- W2370516268 hasPublicationYear "2009" @default.
- W2370516268 type Work @default.
- W2370516268 sameAs 2370516268 @default.
- W2370516268 citedByCount "0" @default.
- W2370516268 crossrefType "journal-article" @default.
- W2370516268 hasAuthorship W2370516268A5000266451 @default.
- W2370516268 hasConcept C112705442 @default.
- W2370516268 hasConcept C179998833 @default.
- W2370516268 hasConcept C185592680 @default.
- W2370516268 hasConcept C18903297 @default.
- W2370516268 hasConcept C2777065887 @default.
- W2370516268 hasConcept C2777379063 @default.
- W2370516268 hasConcept C2777463227 @default.
- W2370516268 hasConcept C2777477808 @default.
- W2370516268 hasConcept C2779858419 @default.
- W2370516268 hasConcept C43617362 @default.
- W2370516268 hasConcept C4725764 @default.
- W2370516268 hasConcept C55493867 @default.
- W2370516268 hasConcept C86803240 @default.
- W2370516268 hasConcept C95986675 @default.
- W2370516268 hasConcept C98274493 @default.
- W2370516268 hasConceptScore W2370516268C112705442 @default.
- W2370516268 hasConceptScore W2370516268C179998833 @default.
- W2370516268 hasConceptScore W2370516268C185592680 @default.
- W2370516268 hasConceptScore W2370516268C18903297 @default.
- W2370516268 hasConceptScore W2370516268C2777065887 @default.
- W2370516268 hasConceptScore W2370516268C2777379063 @default.
- W2370516268 hasConceptScore W2370516268C2777463227 @default.
- W2370516268 hasConceptScore W2370516268C2777477808 @default.
- W2370516268 hasConceptScore W2370516268C2779858419 @default.
- W2370516268 hasConceptScore W2370516268C43617362 @default.
- W2370516268 hasConceptScore W2370516268C4725764 @default.
- W2370516268 hasConceptScore W2370516268C55493867 @default.
- W2370516268 hasConceptScore W2370516268C86803240 @default.
- W2370516268 hasConceptScore W2370516268C95986675 @default.
- W2370516268 hasConceptScore W2370516268C98274493 @default.
- W2370516268 hasLocation W23705162681 @default.
- W2370516268 hasOpenAccess W2370516268 @default.
- W2370516268 hasPrimaryLocation W23705162681 @default.
- W2370516268 hasRelatedWork W1501950790 @default.
- W2370516268 hasRelatedWork W1916668964 @default.
- W2370516268 hasRelatedWork W1964549091 @default.
- W2370516268 hasRelatedWork W1976139556 @default.
- W2370516268 hasRelatedWork W1993581577 @default.
- W2370516268 hasRelatedWork W2035411526 @default.
- W2370516268 hasRelatedWork W2047353496 @default.
- W2370516268 hasRelatedWork W2080342074 @default.
- W2370516268 hasRelatedWork W2122373758 @default.
- W2370516268 hasRelatedWork W2279561981 @default.
- W2370516268 hasRelatedWork W2348056951 @default.
- W2370516268 hasRelatedWork W2348457413 @default.
- W2370516268 hasRelatedWork W2351821058 @default.
- W2370516268 hasRelatedWork W2359177072 @default.
- W2370516268 hasRelatedWork W2371662229 @default.
- W2370516268 hasRelatedWork W2378882615 @default.
- W2370516268 hasRelatedWork W2410095350 @default.
- W2370516268 hasRelatedWork W2768927628 @default.
- W2370516268 hasRelatedWork W2979046682 @default.
- W2370516268 hasRelatedWork W2487167190 @default.
- W2370516268 isParatext "false" @default.
- W2370516268 isRetracted "false" @default.
- W2370516268 magId "2370516268" @default.
- W2370516268 workType "article" @default.