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- W2370525514 abstract "Objective To study the effects of angiotensin Ⅱ receptor blocker (ARB, valsartan) on the extent of neural functional defect and nerve cell apoptosis in renal hypertensive rat models after cerebral ischemia-reperfusion, and investigate the cerebral protective mechanism of ARB. Methods Renal hypertensive Wistar male rat models were established and were then divided randomly into valsartan high dose (12 mg/kg) group (VH group), low dose (6 mg/kg) group (VL group) and ischemia-reperfusion group (IR group). The score of neural functional defect was performed at cerebral ischemia (2 h)-reperfusion (1 h) and ischemia (2 h)-reperfusion (24 h) respectively. The expression of Bcl-2 and Bax were measured by immunohistochemistry. TUNEL was used to analyse the cell apoptosis after cerebral hippocampus ischemia. Results The score of neural functional defect in VH group and VL group was lower than that in IR group (P = 0.047, 0.043). In VH group and VL group, Bcl-2 positive cells were significantly higher (P = 0.000, for all) and Bax positive cells were significantly lower (P = 0.000, for all) than those in IR group. The apoptosis of nerve cell in VH group and VL group were significantly less than that in IR group (P = 0.000, for all). Compared with VL group, Bcl-2 positive cells were significantly higher (P = 0.000), Bax positive cells were significantly lower (P = 0.000) and the reduction of neural cell apoptosis was significant in VH group (P = 0.000). Conclusion Angiotensin Ⅱ receptor blocker (valsartan) can obviously improve the neural function defect, decrease nerve cell apoptosis, upregulate the expression of Bcl-2, and inhibit the expression of Bax in renal hypertensive rat models with focal cerebral ischemia. Angiotensin Ⅱ receptor blocker has certain protective effect on brain tissue after cerebral ischemia-reperfusion injury." @default.
- W2370525514 created "2016-06-24" @default.
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- W2370525514 date "2008-01-01" @default.
- W2370525514 modified "2023-09-24" @default.
- W2370525514 title "Effects of valsartan on cell apoptosis after cerebral ischemia-reperfusion in renal hypertensive rat models" @default.
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