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- W2370529064 abstract "Objective To analyze the key amino acids of the Bacillus anthracis protective antigen(PA) receptor-binding region. Methods Asp~683 was converted into a series of other amino acids by site-directed mutagenesis. Substituted PA proteins were analyzed by cellular cytotoxicity assays to study the influence of charge or dimensional structure of the acid. Furthermore, some variants with neighbor amino acids of Asp~683 were constructed and analyzed by the same way. Results BResults of the cellular cytotoxicity assays showed that different mutations gave rise to different extents of decrease in its toxicity. The influence of the change of related negative charge of Asp~683 was especially evident while Asp~683 was converted into electropositive Lys, it still kept some toxicity. Conclusion The negative charge of Asp~683 plays a very crucial role in the interaction between PA and its receptor, though other mechanisms are potentially present." @default.
- W2370529064 created "2016-06-24" @default.
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- W2370529064 date "2005-01-01" @default.
- W2370529064 modified "2023-09-28" @default.
- W2370529064 title "Analysis of key amino acids of the Bacillus anthracis protective antigen receptor-binding region" @default.
- W2370529064 hasPublicationYear "2005" @default.
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