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- W2370530019 abstract "To explore the effect of intra-bone-marrow injection of bone-marrow cells(IBM-BMT) upon the induction of tolerance to skin allografts,C57BL/6(H-2b,B6) mice received a sublethal dose of total body irradiation with 60Co γ-ray were injected with IBM-BMT of 3×107/30 μl bone marrow cells from BALB/c(H-2d) mice,and cyclophosphamide(CTX) was given intraperitoneally two days after IBM-BMT.Skin grafting and MLR were performed to test the status of immuno-tolerance and chromosome analysis was used to invstigate engrafting of allogeneic bone-marrow cells.The experimental results showed that the mean survival time(MST)of skin allografts in group received IBM-BMT was significantly longer than those of other groups,and MLR assay demonstrated the donor-specific tolerance existing in the recipient mice with a high percentage of donor-derived cells in bone-marrow of tolerant B6 mice on day 45.It is concluded that IBM-BMT can induce a stable state of immuno-tolerance by engrafting the bone-marrow cells." @default.
- W2370530019 created "2016-06-24" @default.
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- W2370530019 date "2006-01-01" @default.
- W2370530019 modified "2023-09-26" @default.
- W2370530019 title "Induction of tolerance skin allografts by intra-bone-marrow injection of bone-marrow cells" @default.
- W2370530019 hasPublicationYear "2006" @default.
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