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- W2370544559 abstract "Objective To study the antitumor activity of Lactobacillus acidophilus(LA)and its effects on immune function in U14-bearing mice.Methods U14-bearing KM mice were randomly divided into 2 groups,one treated with L.acidophilus and a control group.The tumor inhibition rate and spleen index of each group were measured.An MTT assay was used to measure splenic lymphocyte proliferation.Erythrocyte immunity function was evaluated using the rosette-forming rate of erythrocyte C3b receptor(C3b RR)and of immunity complex(ICR).Results Treatment with L.acidophilus markedly inhibited tumor growth in U14-bearing mice,which had a tumor inhibition rate of 48.18%.The spleen index differed significantly(P0.05) for mice treated with L.acidophilus(8.36±2.19) and the control group(5.49±1.09).Splenic lymphocyte proliferation was significantly greater (P0.01) in mice treated with L.acidophilus (25.10±4.33)% compared to the control group (12.90±3.14)%.The rosette-forming rate of C3b RR and ICR differed significantly(P0.05or P0.01)in mice treated with L.acidophilus (4.99%±1.15% and 2.63%±1.84%) compared to the control group (3.67%±1.20% and 8.86%±4.14%).Conclusion L.acidophilus combats tumors in U14-bearing mice by improving erythrocyte immune function and lymphocyte proliferation." @default.
- W2370544559 created "2016-06-24" @default.
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- W2370544559 date "2013-01-01" @default.
- W2370544559 modified "2023-09-26" @default.
- W2370544559 title "Effects of Lactobacillus acidophilus on immune function in U14-bearing mice" @default.
- W2370544559 hasPublicationYear "2013" @default.
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