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- W2370548738 abstract "Objective The MUC2 protein expression in different gastric diseases was investigated,in order to reveal the role of mucin(MUC2) in the development of gastric cancer.Methods Using immunohistochemical methods,the MUC2 expression was detected in 243 cases of different gastric diseases so was also in cases of colorectal cancer(CRC) accompanied by their adjacent tissues as controls.The gastric diseases were composed of superficial gastritis(SG) 87 cases,atrophic gastritis(AG) 87 cases,and gastric cancer(GC) 69 cases which included the high-moderately differentiated adenocarcinoma(HMDA) 27 cases,poorly differentiated adenocarcinoma(PDA) 30 cases,mucinous adenocarcinoma(MA) or signet ring cell carcinoma(SRCC) 12 cases.Eighty cases of colorectal cancer and their adjacent tissues group,included HMDA 30 cases,PDA 26 cases,MA and SRCC 24 cases.Results MUC2 expression in the AG group was significantly higher than that in the SG and GC groups(P0.05);and MUC2 expression in the gastric PDA group was generally low or even with no expression,the positive rate(40%) was significantly lower than that in the MA or SRCC group(75%,P= 0.040).Conclusions The MUC2 can be used as a molecular marker in GA;MUC2 might to be a diagnostic indicator for the identification of PDA and MA/SRCC." @default.
- W2370548738 created "2016-06-24" @default.
- W2370548738 creator A5081687805 @default.
- W2370548738 date "2011-01-01" @default.
- W2370548738 modified "2023-09-25" @default.
- W2370548738 title "Mucin(MUC2)expression in gastric diseases and its clinical significance" @default.
- W2370548738 hasPublicationYear "2011" @default.
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