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- W2370550997 abstract "Objective To explore the effects of irbesartan on exrpession of periostin in myocardium tissue of the viral myocarditis(VMC)mice in chronic phase and myocardial fibrosis,and to clarify the possible mechanism of its antimyocardial fibrosis.Methods The models of VMC in chronic phase were founded by injecting coxsackie virus B3(CVB3)solution into 40BALA/c mice.21VMC mice were divided into model group(n=11)and irbesartan group(n=10).And at the same time,10BALA/C mice were used as control group.The mice in model group and control group were fed with water(1mL·d-1),and the mice in irbesartan group were fed with irbesartan at a dose of 50mg·kg-1·d-1.After 60d,the levels of left ventricular end-diastolic dimension(LVEDd),left ventricular end-systolic dimension(LVEDs)and left ventricular fractional shortening(FS)of the mice in 3groups were examined;the concentrations of AngⅡin the serum of the mice in various groups were detected by ELISA method;the myocardium tissue of mice were stained by MASSON and cardiac collagen volume fraction(CVF)was accounted.At the same time,the contents of periostin mRNA and TGF-β1mRNA in myocardium tissue of mice were detected by RT-PCR method.Results Compared with control group,the levels of LVEDd and LVEDs were increased(P0.01),and the level of FS was decreased(P0.01)in model group;the levels of serum AngⅡ,CVF,TGF-β1mRNA,and periostin mRNA were increased(P0.01)in model group.Compared with model group,the levels of LVEDd and LVEDs of the mice in irbesartan group were obviously decreased(P0.05),and the level of FS was increased(P0.05).There was no significant difference of the levels of serum Ang Ⅱbetween irbesartan group and model group(P0.05),but the levels of CVF,TGF-β1 mRNA,and periostin mRNA of the mice in irbesartan group were obviously decreased compared with model group(P 0.05).Conclusion Irbesartan can offer some protection to myocardial fibrosis inVMC mice.The probable mechanisms may be acted through inhibiting the expression of TGF-β1in myocardium tissue to reduce the expression of periostin." @default.
- W2370550997 created "2016-06-24" @default.
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- W2370550997 date "2013-01-01" @default.
- W2370550997 modified "2023-09-26" @default.
- W2370550997 title "Effect of irbesartan on periostin expression in myocardium tissue of VMC mice in chronic phase and its mechanism of antimyocardial fibrosis" @default.
- W2370550997 hasPublicationYear "2013" @default.
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