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- W2370554306 abstract "The aim of the paper is to investigate the effect of ishchemic preconditioning (PC) on ion homeostasis of isolated cardiomyocytes,and discuss its ion basis of antiarrythmis.Isolated cardiomyocytes were used to study the effect of PC on the cellular concentration of K +,Na +,and the activity of Na + K + ATP ase .Isolated cardiomyocytes were divided into 7 groups.GroupⅠ=PC;GroupⅡ=PC+Glibenclamide(GLB);GroupⅢ=PC+Ouabain(OUB);GroupⅣ=anoxic reoxygenated (AR);GroupⅤ=Cromakalim(CRK)+AR;GroupⅥ=OUB+CRK+AR;GroupⅦ=Control.Results: From anoxic reoxygenated cycle 1 to 2 and 3,concentration of extracellular potassium increased gradually which could be block by GLB.After exposure to anoxic reoxygenated,the activity of Na + K + ATP ase in Group Ⅰ was maintained at higher level (6.42±0.8 μmol·mg -1 ·h -1 ) with higher intracellular potassium concentration (386.5±83.33 μg/mg) and lower intracellular sodium concentration (372.5±57.27 μg/mg).GLB blocked the protective effect of PC in Group Ⅱ with lower activity of Na + K + ATP ase (3.62±0.96 μmol·mg -1 ·h -1 ) and higher intracellular sodium concentration 518.67±61.18 mg.protein/hr),OUB also blocked the protective effect of PC with lower activity of Na + K + ATP ase (1.61±0.57 μmol·mg -1 ·h -1 ),lower intracellular potassium concentration (87.67±18 μg/mg) and higher intracellular sodium concentration (732.54±54.4 μg/mg).The leakage of LDH had a corresponding change with the activity of Na + K + ATP ase .Conclusion:PC promoted the opening of ATP sensitive potassium channel and alleviated the cellular injury,in turn maintained the activity of ATP sensitive of Na + K + ATP ase and ion homeostasis.It may be one of the mechanisms of PC suppressing arrhythmias.[Chinese Journal of Cardiac Pacing and Electrophysiology,2000,14(3):191～194]" @default.
- W2370554306 created "2016-06-24" @default.
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- W2370554306 date "2000-01-01" @default.
- W2370554306 modified "2023-09-25" @default.
- W2370554306 title "Effect of Ischemia Preconditioning on Ions Homeostasis of Anoxic Reoxygenated Cardiomyocytes of SD Rats." @default.
- W2370554306 hasPublicationYear "2000" @default.
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