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- W2370556438 abstract "Objective:To appraise the in vivo effects of the 3rd generation βadrenergic receptor blocker carvedilol(CVD) on the myocardial ultrastructure in a rat model of acute myocardial ischemia reperfusion injury. Methods:8 rats of the treatment group were given each a daily dose of 1 mg·kg 1 of CVD through a stomach tube for 7 consecutive days before the induction of myocardial infarction. No drug was given in the 8 rats of the control group. Myocardial infarction (MI) was induced by ligation of the left anterior descending branch of the coronary artery(LAD) for 30 min. Untying of the ligation was followed by 360 min of reperfusion. The animals were sacrificed at the termination of reperfusion for further study. Serum lactate dehydrogenase (LDH), CK MB, and MDA were determined. Tissue samples removed from the infarcted areas were examined by light microscopy and electron microscopy. Results:In CVD treated rats, the release of LDH, CK MB, and MDA were reduced( P 0.05). In the myocardial tissue of the control animals, patchy or focal necrosis of myocytes, disorganization of intercalated discs and extensive infiltration of reactive neutrophil granulocytes among necrotic myocytes were demonstrated under the light microscope and electron microscope. In animals of the CVD treated group, the injury of myocytes as well as the infilhation of granulocylus was much less prominent and the structure of intercalated discs was basically normal. Conclusion:CVD was shown to provide an evident protective effect on ischemia reperfusion myocardium." @default.
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- W2370556438 date "2002-01-01" @default.
- W2370556438 modified "2023-09-24" @default.
- W2370556438 title "Effects of Carvedilol on Myocardial Ultrastructure in a Rat Model of Acute Myocardial Ischemia-reperfusion Injury" @default.
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