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- W2370558990 abstract "Objective To study the cytotoxicity of keratin 19 promoter-driven HSV-TK in cancer cell lines.Methods The promoter region of mice keratin 19 was amplified using PCR from genomic DNA and cloned into a vector containing the encoding region of HSV-TK to construct a new plasmid pK19-TK. After transfection of the plasmid into several cancer cells lines,including tranformed mouse keratinocytes cell line,human lung carcinoma cell line and two cervical cancer cell lines,cytotoxicity of ganciclovir to tumor cells was assayed by both MTT assay and flow cytometry.Results In carcinoma cell lines which had higher keratin 19 expression than respective normal cells,significant apoptesis occurred in two cell lines in the presence of ganciclovir.In Pam212 cell line,19.4%,44.4% and 58.7% of the cells were killed after exposed to GCV at concentrations of 2,10 and 100μmol/L respectively.Conclusion Cancer cells death induction utilizing the keratin expression pattern is of potential value to the treatment of epithe- lial-derived tumors." @default.
- W2370558990 created "2016-06-24" @default.
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- W2370558990 date "2007-01-01" @default.
- W2370558990 modified "2023-09-26" @default.
- W2370558990 title "Anti-tumor activity by targeting the keratin-19 positive cells in carcinoma cell lines" @default.
- W2370558990 hasPublicationYear "2007" @default.
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