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- W2370593018 abstract "Objective To investigate the mutation type and sites of HBV DNA and the therapeutic effects of adefovir dipivoxil(ADV) on patients with chronic hepatitis B(CHB).Methods HBV DNA was amplified by PCR.The PCR products were sequenced using Prosequence 96MA sequenator.The sequencing data were analyzed by sequencing software.Forty-three CHB patients with multi-mutation were Treated by ADV 10 mg daily for 48 weeks.The clinical data before and after switch were collected.Results Ttwenty-eight patients were found to have YMDD mutations.The mutation types were rtL180M/M204V、rtM204I、rtL180M/M204I.Single mutation and multi-mutation were found at the same time.Seven patients had G1896A mutant,4 had V214A、V173L mutant and 4 had G1896A、L180M、M204I、M204V multi-mutation.ADV could significantly suppress the replication of HBV mutant strain.HBV DNA level was decreased from(6.28 ± 1.09) log10 copy/ml before switch to(4.14 ± 1.02)log10 copy/mland(3.91 ± 0.85) log10 copy/ml after switch to ADV for 24 and 48 weeks.Alanine aminotransferase normalization rate were 51.1%,67.4% at 24 and 48 weeks(all P 0.01).No adverse events were found by detecting blood routine,urine routine,renal function after treatment with ADV.Conclusions ADV is effective on CHB patients with multi-mutation." @default.
- W2370593018 created "2016-06-24" @default.
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- W2370593018 date "2012-01-01" @default.
- W2370593018 modified "2023-09-26" @default.
- W2370593018 title "Detection of hepatitis B virus gene variations and adefovir dipivoxil treatment in patients with chronic hepatitis B" @default.
- W2370593018 hasPublicationYear "2012" @default.
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