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- W2370615870 abstract "Objective To reproduce conditions that were clinically known to be associated with an increased propensity to the development of torsade de pointes(TDP) by perfusion terfenadine in isolated rabbit heart,and investigate the mechanism of torsade de pointes and proarrythmia potency of the medicine.Methods The isolated rabbit hearts,with cauterize-induced Ⅲ° atrio-ventricular block(AVB),were perfused by the non-recirculating Langendorff technique and used a variety of pacing cycle length.Early after depolarizations(EADs) and TDP were induced by abrupt changes of cycle length in the presence of Tyrode's solution containing terfenadine and 50% reduced the concentration of potassium and magnesium(low K~+ and Mg~(++)).Results No early after depolarizations(EADs) and triggered activity (TA) or TDP was induced with tyrodes solution and modified tyrode's solution.Compared with baseline,terfenadine prolonged QT interval and MAPD_(90) at different concentration with different pacing cycle length,which was from 400ms to 2 400ms.EADs were recorded in 10/18 rabbit hearts.TDP episodes were induced by terfenadine(concentration was 1×10~(-6),2×10~(-6),4×10~(-6) and 8×10~(-6)M,respectively) concurrently with modified Tyrode's solution when the pacing cycle length was more than 1 600ms in 3/18(16.7%) hearts studied and was induced by abrupt changes of cycle length in 7/18(38.1%) hearts.All episodes of TDP terminated spontaneously.Conclusion In this Langendorff perfused rabbit hearts,terfenadine prolonged MAPD_(90) at different concentration with different pacing cycle length.TDP can be induced by abrupt changes of cycle length in the presence of the modified tyrode's solution containing terfenadine.EADs are associated with TDP." @default.
- W2370615870 created "2016-06-24" @default.
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- W2370615870 date "2006-01-01" @default.
- W2370615870 modified "2023-09-28" @default.
- W2370615870 title "Themimicing of torsade de pointes model induced by terfenadine in non-recirculating langendorff technique" @default.
- W2370615870 hasPublicationYear "2006" @default.
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