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- W2370640185 abstract "Objectives:To evaluate serum β-HCG and VEGF concentrations in women with rupture of tubal pregnancy(rTP),tubal abortion(TA) and spontaneous abortion(SA) at about 6 weeks of gestation.Methods:This was a prospective,case-control study evaluating serum β-HCG and VEGF concentrations among 63 women with the symptom of abdominal pain or vaginal bleeding who subsequently were confirmed rTPs(n=21),TAs(n=14),SAs(n=27).One suspected TP proved to be normal intrauterine pregnancy and was excluded.β-HCG,and VEGF were measured by RIA and ELISA methods respectively.Results:The median β-HCG concentrations in rTPs and TAs were statistically higher than that in SAs(3070.70±1069.68,2632.21±840.60,1674.05±727.88mIU/ml respectively,P0.01,P0.01).With a cut-off value of 1 880 mIU/ml,serum β-HCG could discriminate TPs from SAs with a sensitivity of 88.6%,a specificity of 66.7% and a positive predictive value of 77.5%.The median VEGF concentration in rTPs was statistically higher than that in TAs and SAs(254.87±78.52,105.81±38.11,118.32±52.94 pg/ml respectively,P0.01,P0.01).Based on the combined measurement of serum β-HCG,and with a cut-off value of 179pg/ml,serum VEGF could discriminate rTPs from TAs with a sensitivity of 85.7%,a specificity of 100% and a positive predictive value of 100%.Conclusion:It is a useful marker that the combined measurement of serum β-HCG and VEGF predicts the rupture of tubal pregnancy at about 6 weeks of gestation." @default.
- W2370640185 created "2016-06-24" @default.
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- W2370640185 date "2010-01-01" @default.
- W2370640185 modified "2023-09-23" @default.
- W2370640185 title "The value of the combined measurement of serum β-HCG and VEGF for predicting early rupture of tubal pregnancy" @default.
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