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- W2370642444 abstract "Objective To investigate antitumor effect of allotri-tridecyl diethylamine(D-108) in vivo. Methods D-108 was administrated to mice with transplanted solid tumors U14 and ascitic cancer HAC.Tumor weight of U14 and survival time of the mice implanted HAC were observed.The acute toxicity on mice was observed via different administration routes of D-108. Results D-108 intraperitoneal injection(ip) and intragastric administration(ig) could effectively inhibit in vivo growth of implanted solid tumor U14 in mice.The inhibition rates of tumor weight of D-108 12 mg/(kg·d)(ip) and 100 mg/(kg·d)(ig) were 38.54% and 45.27%,respectively.D-108 subcutaneous injection(sc) and ig could prolong the survival time of mice implanted with ascitic cancer HAC.The rates of life extension of the mice with D-108 20 mg/(kg·d)(sc) and 100 mg/(kg·d)(ig) were 36.30% and 39.43%,respectively.LD_(50) of D-108 in mice were 43.7 mg/kg(ip),230.9 mg/kg(sc) and 415.1 mg/kg(ig) by Bliss method. Conclusion D-108 has obvious antitumor activity in vivo in different administration routes." @default.
- W2370642444 created "2016-06-24" @default.
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- W2370642444 date "2007-01-01" @default.
- W2370642444 modified "2023-10-17" @default.
- W2370642444 title "Antitumor activity of allotri-tridecyl diethylamine in vivo" @default.
- W2370642444 hasPublicationYear "2007" @default.
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