Matches in SemOpenAlex for { <https://semopenalex.org/work/W2370647510> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2370647510 abstract "Objective: This study was to investigate the implication of abnormal PepT1 on rat colonic inflammation by transporting fMLP. Methods: Small bowel resection was adopted to upregulate the PepT1 expression in the colon in rats. The inflammatory effects of PepT1-mediated fMLP transport on the bowel resection rat colon were investigated by means of adopting myeloperoxidase (MPO) activity and histological analysis. Gly-Gly was used to block the PepT1 to determine the role of PepT1 in colonic inflammation. Results: We found a peak of expression of PepT1 at post-operation week 2 with declining levels to 25% at week 4. The ability of adapting rat colon to transport oligopeptide decreased with the colonic PepT1 diminished. 10 μmol/L fMLP perfusion for 4 h in the colon of bowel resection rat at week 2 after the operation resulted in increased MPO activity and mucosal inflammation, but did not result in any measurable changes in these parameters when administered at week 4 following surgery. The inhibition of PepT1 by administering 50 Mm Gly-Gly inhibited both activation of MPO activity and colonic mucosal damage induced by fMLP. Conclusion: The colonic PepT1 induced by bowel resection provide a mechanism for transport of oligopeptide as well as bacterial product fMLP. Abnormal colonic epithelial PepT1 may serve as a potential way to colon mucosa damage in rats." @default.
- W2370647510 created "2016-06-24" @default.
- W2370647510 creator A5004973460 @default.
- W2370647510 date "2007-01-01" @default.
- W2370647510 modified "2023-09-23" @default.
- W2370647510 title "Pathology feature of abnormal PepT 1 in colon mucosa in rat" @default.
- W2370647510 hasPublicationYear "2007" @default.
- W2370647510 type Work @default.
- W2370647510 sameAs 2370647510 @default.
- W2370647510 citedByCount "0" @default.
- W2370647510 crossrefType "journal-article" @default.
- W2370647510 hasAuthorship W2370647510A5004973460 @default.
- W2370647510 hasConcept C104317684 @default.
- W2370647510 hasConcept C126322002 @default.
- W2370647510 hasConcept C127561419 @default.
- W2370647510 hasConcept C142724271 @default.
- W2370647510 hasConcept C146957229 @default.
- W2370647510 hasConcept C185592680 @default.
- W2370647510 hasConcept C203565725 @default.
- W2370647510 hasConcept C2776914184 @default.
- W2370647510 hasConcept C3019368612 @default.
- W2370647510 hasConcept C55493867 @default.
- W2370647510 hasConcept C71924100 @default.
- W2370647510 hasConcept C90924648 @default.
- W2370647510 hasConceptScore W2370647510C104317684 @default.
- W2370647510 hasConceptScore W2370647510C126322002 @default.
- W2370647510 hasConceptScore W2370647510C127561419 @default.
- W2370647510 hasConceptScore W2370647510C142724271 @default.
- W2370647510 hasConceptScore W2370647510C146957229 @default.
- W2370647510 hasConceptScore W2370647510C185592680 @default.
- W2370647510 hasConceptScore W2370647510C203565725 @default.
- W2370647510 hasConceptScore W2370647510C2776914184 @default.
- W2370647510 hasConceptScore W2370647510C3019368612 @default.
- W2370647510 hasConceptScore W2370647510C55493867 @default.
- W2370647510 hasConceptScore W2370647510C71924100 @default.
- W2370647510 hasConceptScore W2370647510C90924648 @default.
- W2370647510 hasLocation W23706475101 @default.
- W2370647510 hasOpenAccess W2370647510 @default.
- W2370647510 hasPrimaryLocation W23706475101 @default.
- W2370647510 hasRelatedWork W1562821701 @default.
- W2370647510 hasRelatedWork W1900915098 @default.
- W2370647510 hasRelatedWork W1991437192 @default.
- W2370647510 hasRelatedWork W1995230220 @default.
- W2370647510 hasRelatedWork W1997225138 @default.
- W2370647510 hasRelatedWork W2003700697 @default.
- W2370647510 hasRelatedWork W2013594559 @default.
- W2370647510 hasRelatedWork W2027119200 @default.
- W2370647510 hasRelatedWork W2028636313 @default.
- W2370647510 hasRelatedWork W2029307482 @default.
- W2370647510 hasRelatedWork W2029667275 @default.
- W2370647510 hasRelatedWork W2030955558 @default.
- W2370647510 hasRelatedWork W2052356145 @default.
- W2370647510 hasRelatedWork W2062875581 @default.
- W2370647510 hasRelatedWork W2081059302 @default.
- W2370647510 hasRelatedWork W2083285179 @default.
- W2370647510 hasRelatedWork W2132122176 @default.
- W2370647510 hasRelatedWork W2365558459 @default.
- W2370647510 hasRelatedWork W2381522844 @default.
- W2370647510 hasRelatedWork W2485997503 @default.
- W2370647510 isParatext "false" @default.
- W2370647510 isRetracted "false" @default.
- W2370647510 magId "2370647510" @default.
- W2370647510 workType "article" @default.