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- W2370661159 abstract "[Objective] To observe the changes of serum neuron-specific enolase and S100B in neonates with hypoxic ischemic encephalopathy (HIE) treated with Ganglioside (GAs) and its clinical significance. [Methods] 89 term neonates with HIE were randomly taken and divided into two groups: GAs treatment group (45 cases) and routine treatment group (44 cases), 20 cases of normal newborns as the control group. The conventional treatment was the same in the two groups of children with HIE, but in GAs treatment group, the neonates were treated with monosialotetrahexosy ganglioside (GM1) 20 mg once a day for 10 days on the basis of the conventional treatment. The NSE and S100B in serum were determined in 89 term neonates with HIE before and after the treatment, and in the 20 cases of normal newborns before the treatment. [Results] The difference was not statistically significant, NSE (131.24 ± 44.59), S100B (2.14 ± 1.68) in GAs treatment group and NSE (125.92 ± 45.03), S100B (2.55 ± 1.62) in routine treatment group, before treatment, while the NSE and S100B in neonates with HIE were significantly higher than NSE (29.00 ± 8.96), S100B (0.16 ± 0.09) in the control. The NSE (22.57 ± 8.85), S100B (0.20 ± 0.14) in GAs treatment group were significantly lower than NSE (28.75 ± 16.00), S100B (0.35 ± 0.25) in routine treatment group. [Conclusion] NSE, S100B can be used as indicators of HIE, and intravenous monosialotetrahexosy ganglioside (GM1) is efective in treating HIE." @default.
- W2370661159 created "2016-06-24" @default.
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- W2370661159 date "2011-01-01" @default.
- W2370661159 modified "2023-09-24" @default.
- W2370661159 title "EFFECT OF GANGLIOSIDE ON SERUM NEURON-SPECIFIC ENOLASE AND S100B IN NEONATES WITH HYPOXIC ISCHEMIC ENCEPHALOPATHY" @default.
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