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• W2370662574 abstract "Objective: Study of the clinical significance of early diagnosis and therapeutic effect evaluation with detection of serum galactomannan(GM) antigen for hematologic disease patients with invasive aspergillosis(invasive aspergillosis, IA). Methods:137 cases of patients with IFD disease risk factors of invasive fungal and with 468 serum samples of GM test were chosen to detect the change of GM antigen levels after antifungal treatment, to collect the clinical data and the statistical analysis of the patients, and to evaluate the diagnostic value of GM test for invasive aspergillosis in patients with hematologic disease. Results: We used the detection of GM single I≥1 as a positive value, and sensitivity, specificity, positive predictive value and the negative predictive value was 90.91%,95.65, 95.24% and 91.67% respectively. Compared with the serum GM test results provided with the kit of single I ≥1.5 positive threshold sensitivity increased significantly with no significant decrease, but the specificity. Therefore, it could effectively distinguish between clinical diagnosis and two suspected IA levels. The GM test is added to the basic examination in other laboratory tests and imaging on clinical diagnosis. The number of IA group increased significantly. Diagnostic level and I value has a correlation between the distribution of population mean. The I value is distributed obviously from high to low level of the community with retrospective diagnosis of IA group, retrospective of suspected IA patients and retrospectively excluded IA group. The I values distribution range had significant differences between the three diagnostic levels. According to the positive critical value of standard I≥1, GM test of positive appeared earlier than in sputum culture of positive for an average of 7.73±8.71 d and also earlier than in CT imaging evidence for an average of6.89 ±8.02 d. The value of GM positive when the preemptive antifungal therapy group improved efficiency based on(P=0.039).Conclusion: The detection of serum GM antigen is an effective method for an earlier diagnosis of IA.When we use the single I ≥1 as positive threshold, it has better sensitivity and specificity. In the positive rate and positive time GM test has some advantages than the main radiological and microbiological evidence. According to GM test positive for preemptive antifungal therapy, it can improve the treatment efficiency in patients with high-risk hematologic disease and agranulocytosis. Important value of dynamic monitoring the changes of serum concentration of GM has evaluated the efficacy of. It has certain guiding significance in diagnosis and treatment of the results of clinical invasive aspergillosis." @default.
• W2370662574 created "2016-06-24" @default.
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• W2370662574 date "2014-01-01" @default.
• W2370662574 modified "2023-09-23" @default.
• W2370662574 title "Diagnostic Value of GM Test of Invasive Aspergillosis in Patients with Hematologic Disease" @default.
• W2370662574 hasPublicationYear "2014" @default.
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