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- W2370662981 abstract "Objective To study the clinical characterustics of drug eruption caused by carbamazepine. Methods The clinical data of 8 inpatients with drug eruptions resulted from carbamazepine were subjected to an analysis including indications of the drug,latent period of eruption,features of the lesions of the skin,mucous membrane and internal organs as well as the response of the patients to the treatment. Results The average latent period of the eruption in the 8 patients was(13.9±5.9) days and the clinical manifestations varied in these patients.1 case of mild erythema multiforme(MEM),1 case of toxic epidermal necrolysis(TEN),3 cases of severe erythema multiforme(SEM),and 3 cases of SEM complicated by TEN were diagnosed.Severe types of the drug eruption in adults were usually associated with lesion of visceral organs usually those of the liver and kidney.The therapeutic effect of large dosis of γ-globulin instilled intravenously was fairly good in the treatment of patients with severe types of drug eruption who responded not very well to glueocorticoids.The average effective dose of prednisone in 5 of the 7 patients with severe drug eruption was 1.5 mg·kg-1·d-1. Conclusion The average latent period of drug eruption caused by carbamazepine was approximately 2 weeks.Severe types of drug eruption developed in a short period in the majority of cases.Timely withdrawal of the drug and full dose of glucocorticoids may be crucial for preventing the patients from developing TEN or SEM/TEN.An optimal dose of glucocorticoids equivalent to 1.2-2.0 mg·kg-1 of prednisome with or without large dose of intravemous γ-globulin infusion proved to be fairly effective in the treatment of drug eruptions and no major adverse reactions of glueocorticoids were encountered within 4 weeks." @default.
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- W2370662981 date "2007-01-01" @default.
- W2370662981 modified "2023-09-26" @default.
- W2370662981 title "An Analysis of the Clinical Characteristics of Drug Eruption Caused by Carbamazepine" @default.
- W2370662981 hasPublicationYear "2007" @default.
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