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- W2370679259 abstract "OBJECTIVE: To study the effect of selenium chitosan on anti-oxidative ability in NB4 cells in patients with acute promyelocytic leukemia(APL) and its correlation with the NF-κB signaling molecules.METHODS: NB4 cells were treated with different concentrations of selenium chitosan(50,100,200 mg·L-1) for 24 h before the supernatant was taken for the determination of levels of GSH-px,SOD,MDA,and NF-κB signal protein molecules,with culture solution set as control.RESULTS: Compared with the control group,exposure of NB4 cells to different concentrations of selenium chitosan for 24 h could significantly increase GSH-px activity(P0.01),decrease SOD activity and MDA content(P0.01 or P0.05),and decrease the level of NF-κB in obvivous dose-effect relationship(P0.01).CONCLUSION: Selenium chitosan downregulates gene expresxion of its downstream by reducing the level of NF-κB entering into nucleus and inhibits the proliferation of NB4 cells and induces apoptosis by enhancing the anti-oxidative ability of cells." @default.
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- W2370679259 date "2008-01-01" @default.
- W2370679259 modified "2023-09-23" @default.
- W2370679259 title "Effect of Selenium Chitosan on the NB_4 Cells and Its Correlation with NF-κB Signaling Molecules" @default.
- W2370679259 hasPublicationYear "2008" @default.
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