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- W2370680267 abstract "Objective To explore the effects of rosiglitazone on blood lipids,plasma, vascular and myocardial angiotensin Ⅱ(Ang Ⅱ) as well as tumor necrosis factor-α(TNF-α) in rats with diet-induced hypercholesterolemia. Methods Rats were randomly divided into four groups: regular diet group(N, n=6),high-cholesterol diet group(G, n=10), rosiglitazone-treated group(L, n=10)and irbesartan-treated group(A, n=10). At the end of 24 weeks, blood lipids,TNF-α and AngⅡ levels were determined. Results Serum TC,TG,LDL,TNF-α levels in the high-cholesterol diet group were significantly higher than those in the other three groups. Cardiovascular tissue TNF-α and AngⅡ levels remarkably increased in high-cholesterol diet group, and were decreased by rosiglitazone and irbesartan. Conclusion The present findings suggest that rosiglitazone can not only reduce blood lipids, but also remarkably attenuate vascular and myocardial local TNF-α and AngⅡ levels in hypercholesterolemia rats. Rosiglitazone may exert anti-inflammatory and anti-atherosclerosis effects through modulating RAS and cell factors." @default.
- W2370680267 created "2016-06-24" @default.
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- W2370680267 date "2008-01-01" @default.
- W2370680267 modified "2023-09-27" @default.
- W2370680267 title "Effects of rosiglitazone on level of angiotensin II in male rats with diet-induced hypercholesterolemia" @default.
- W2370680267 hasPublicationYear "2008" @default.
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