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- W2370697500 abstract "Objective To determine the effects of IL 1β and TNF α on the proliferation and c Fos, c Jun of osteoblasts in vitro. Methods Osteoblast cells from rat calvaria were isolated by sequential enzymatic digestion. With 48 hours treatment of various concentration IL 1β and TNF α, the proliferation of osteoblasts was measured by tetrazolium salt (MTT) method, and c Fos and c Jun of osteoblasts with the treatment of IL 1β and TNF α for various durations were detected by the immunohistochemistry combined with computer based image analysis method. Results Both IL 1β and TNF_α were able to stimulate osteoblast proliferation. Osteoblasts were preincubated by indomethacin for 2 hours, and then treated with IL 1β (100U/ml) or TNF α(10U/ml) for 48 hours. The results showed that indomethacin could not block the osteoblast proliferation effect induced by IL 1β or TNF α. Meanwhile, c Fos and c Jun of osteoblasts increased at 30 min after the stimulation of IL 1β and TNF α, with a maximum at 60 min and 120 min respectively, and decreased afterward. Conclusion IL 1β and TNF α are able to directly stimulateratcalvariaosteoblastproliferation, and c Fos and c Jun of osteoblasts increase rapidly, which probablymediatedtheeffectof IL 1β and TNF_α on osteoblast proliferation." @default.
- W2370697500 created "2016-06-24" @default.
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- W2370697500 date "2000-01-01" @default.
- W2370697500 modified "2023-09-25" @default.
- W2370697500 title "Effects of interleukin-1βand tumor necrosis factor-α on the proliferation of osteoblasts in vitro" @default.
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