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- W2370717024 abstract "Objective To study the role of endothelin(ET) in the pathogenesis of traumatic shock by observing the effect of caffeic acid (CFA),a new kind of endothelin antagonist in the therapy of traumatic shock rats.Methods Traumatic shock models in Sprague Daulay rats were made and randomly divided into 4 groups based on occasion of CFA treatment: group A (no remedy),B (before injury),C (the moment of resuscitation) and D (3 h after resuscitation).Plasma ET levels and oxygen partial pressure in tissues including skeletal muscles,liver and small intestine were detected at 5th h after resuscitation.Meanwhile,hemodynamic data and survival time of the rats were monitored and recorded.Results Plasma ET levels in groups B,C and D at 5th h after resuscitation were significantly lower than those in group A ( P 0.05).There were statistically significant difference in tissues oxygen partial pressure and the mean survival time detected at 5th h after resuscitation between group B and group A.On the contrary,treatment of group D could significantly improve tissue oxygen partial pressure and prolong the mean survival time.Conclusion Endothelin plays important roles of maintaining the blood pressure in the forepart of traumatic shock.Treatment of CFA in forepart of shock can shorten the mean survival time of the animal models while in anaphase may significantly improve tissue oxygen partial pressure and prolong the mean survival time." @default.
- W2370717024 created "2016-06-24" @default.
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- W2370717024 date "2003-01-01" @default.
- W2370717024 modified "2023-09-25" @default.
- W2370717024 title "Effect of endothelin antagonist on traumatic shock in rats" @default.
- W2370717024 hasPublicationYear "2003" @default.
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