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- W2370721844 abstract "Objective:To investigate the change of [Ca2+]i in type 2 diabetes mellites patients and its relationship with insulin receptor tyrosine kinase activity. Methods: The [Ca2+]i was assayed with fluorescence spectroscopic analysis and the insulin receptor tyrosine kinase activity was assayed with enzyme-linked immunosorbent assay method in circulating mononuclear cells in 40 type 2 diabetes mellites patients and 20 normal subjects. Results:The [Ca2+]i of circulating mononuclear cells in type 2 diabetes mellites patients was significantly higher than that in normal controls. The insulin receptor tyrosine kinase activity was significantly decreased in patients. The [Ca2+]i of circulating mononuclear cells in type 2 diabetes mellites patients was positively correlated with FBG, FINS, and negatively with the insulin receptor tyrosine kinase activity. Conclusion: The results suggest that elevation of [Ca2+]i may affect the insulin receptor tyrosine kinase activity and thus contributes to the insulin resistance." @default.
- W2370721844 created "2016-06-24" @default.
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- W2370721844 date "2002-01-01" @default.
- W2370721844 modified "2023-09-28" @default.
- W2370721844 title "Study on the changes of cytosolic free calcium concentration in type 2 diabetes mellitus patients" @default.
- W2370721844 hasPublicationYear "2002" @default.
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