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- W2370726087 abstract "OBJECTIVE To investigate the influence of novel anticancer drug para toluene sulfonamide(PTS) on CYP3A2,CYP2D1,CYP1A2 activities,P-gp,and drug interactions in rats.METHODS Male Wistar rats were pretreated with ip phenobarbital(PB),ketoconazole(Ket),verapamil(Ver) for 3 d and in situ rat liver perfusion in a recirculation system was conducted for 1 h with PTS preparation;Male Wistar rats were pretreated with ip PTS 33 and 99 mg·kg~(-1)·d~(-1) for 4 d and dextromethorphan(Dex) and phenacetin(Phe) liver perfusions were conducted.Different concentrations of PTS were incubated with Dex and Phe in microsome;Different concentrations of VP-16 and 5-FU were incubated with PTS in microsome.RESULTS The metabolism of PTS was induced in PB-treated group and inhibited in ket-treated group.No metabolism difference between control and Dex/Phe treated groups was found.VP-16 inhibited PTS metabolism by 50.7% compared with negative control,while 5-FU had no influential effect.CONCLUSION In situ liver perfusion is an appropriate organ model for drug metabolism and disposition research.Liver CYP450 is responsible for PTS metabolism.PTS rat liver metabolism has no influential effect to CYP3A2,CYP2D1,CYP1A2 activities.P-glycoprotein inhibited by Ver has no significant effect on PTS metabolism at the experiment conditions.VP-16 has inhibitory impact on PTS which need more investigation in clinical use." @default.
- W2370726087 created "2016-06-24" @default.
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- W2370726087 date "2006-01-01" @default.
- W2370726087 modified "2023-09-25" @default.
- W2370726087 title "Research on Influence of in situ Liver Perfusion and Microsomal Incubation on Para Toluene Sulfonamide Liver Metabolism in Rat" @default.
- W2370726087 hasPublicationYear "2006" @default.
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