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- W2370726616 abstract "Objective:To establish an UV method to determinate vitro releasing ratio of mefformin hydrochloride en- teric-coated capsules.Methods:An UV method was applied to determinate vitro releasing ratio of metformin hydrochloride enteric-coated capsules in 0.1 mol·L~(-1)hydrochloric acid solution and pH 6.8 phosphate buffer saline.Results:The outcome of the vitro releasing ratio of mefformin hydrochloride enteric-coated capsules in 0.1 mol·L~(-1)hydrochloric acid solution was not accurate when determinated with the method following the state drug specification,and the recovery was only 40.5%;we adjusted the pH of the sample of 0.1 mol·L~(-1)hydrochloric acid solution to pH 6.8 by adding 0.2 mol·L~(-1)sodium phosphate,and the recovery reached 100.3%.Conclu- sion:The method of the state drug specification to determinate vitro releasing ratio of metformin hydrochloride enter- ic-coated capsules in 0.1 mol·L~(-1)hydrochloric acid solution is unreasonable and must to be adjusted." @default.
- W2370726616 created "2016-06-24" @default.
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- W2370726616 date "2007-01-01" @default.
- W2370726616 modified "2023-09-23" @default.
- W2370726616 title "Study on the method for determinate in vitro releasing ratio of metformin hydrochloride enteric-coated capsules" @default.
- W2370726616 hasPublicationYear "2007" @default.
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