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- W2370731058 abstract "OBJECTIVE To prepare the matrine boric acid vaginal bioadhesive supposi-tory,to investigate their drug release in vitro and compare the clinical efficacy of the matrine boric acid vaginal bioadhesive suppository in the treatment of vulvovaginal candidiasis with Baofukangshuang.METHODS The release medium was various pH(3,4,5,6) buffer phosphate.The drug release rate in vitro was determined by HPLC to observe the delivery be-havior in vitro.120 patients with vulvovaginal candidiasis were randomly divided into two groups.60 patients of the test group were treated with the matrine boric acid vaginal bioadhe-sive suppository while the control group of 60 patients were treated with Baofukangshuang.Then the efficacy of the two groups was compared.RESULTS The delivery behavior of the vaginal suppository in various pH buffer phosphates was that matrine and boric acid delayed release and the release model was consistent with zero-order release equation.The effective rate of the treated group was 81.67%,and the rate of the control group was 73.33%.There was no significant difference between the two groups(P 0.05).CONCLUSION The delivery behavior of the matrine boric acid vaginal bioadhesive suppository in vitro fit the request of controlled release preparation.The matrine boric acid vaginal bioadhesive suppository has good effect on the treatment of vulvovaginal candidiasis." @default.
- W2370731058 created "2016-06-24" @default.
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- W2370731058 date "2014-01-01" @default.
- W2370731058 modified "2023-09-26" @default.
- W2370731058 title "Dissolution of matrine boric acid vaginal bioadhesive suppository in vitro and its clinical observation" @default.
- W2370731058 hasPublicationYear "2014" @default.
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