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- W2370743381 abstract "Objective To evaluate the influence of the airway inflammation and hyperresponsiveness in cough variant asthma treated by the inhaled corticosteroids. Methods Thirty patients with cough variant asthma were selected as the observation group, seen in our hospital from July 2011 to July 2012, and 30 cases of physical healthy people as control group in the same period. Before treatment, the two groups underwent lung function,bronchial provocation tests, and the induced sputum examination. Then the patients in observation group were given budesonide inhalation therapy and followed for 1 year. PD20-FEV1 values, levels of IL-5 and IL-10 and the eosinophils ratio of induced sputum in observation group were assessed before treatment and 3, 6, 9 and 12 months after treatment. Results Before treatment, IL-5 level and eosinophils ratio of induced sputum in the observation group was significantly higher than those in the control group, while IL-10 level was significantly lower than that in the control group. All the differences had statistically significance(P0.05). The PD20-FEV1 was obviously improved3 months after treatment. The airway hyperresponsiveness was very mild 12 months after treatment, but the negative conversion ratio is only 53.3%(16/30). Compared with the control group, levels of IL-5 and IL-10 and the eosinophils ratio of induced sputum in the observation group were significantly changed at all the time nodes after treatment(P0.05). Conclusion Inhaled glucocorticoid treatment for 1 year could significantly reduce airway inflammation and hyperresponsiveness in patients with cough variant asthma, but longer maintenance treatment was needed for complete subside of airway inflammation and negative conversion of airway hyperresponsiveness." @default.
- W2370743381 created "2016-06-24" @default.
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- W2370743381 date "2014-01-01" @default.
- W2370743381 modified "2023-09-24" @default.
- W2370743381 title "Influence of the airway inflammation and hyperresponsiveness in cough variant asthma treated by the inhaled corticosteroids" @default.
- W2370743381 hasPublicationYear "2014" @default.
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