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- W2370760605 abstract "Objective To study the correlation of isoniazid concentrations between saliva and serum in patients with epilepsy.Methods 202 patients in Central Hospital of Changsha between Sep.2007 and Mar.2009 were selected,At the steady drug concentration,2.0 ml of blood samples was obtained by phlebotomy and 1.0 ml of saliva samples was collected at the same time.Serum and salivary isoniazid concentrations were determined by high performance liquid chromatography.Results Linear regression analysis was made of the isoniazid concentration(C)and the peak area(A).The regression equation of the serum concentration and saliva concentration was C=1.34×10-5A-0.25(r=0.9958)and C=4.07×10-6A-0.30(r=0.9921),The correlation between the isoniazid serum concentration(X)and saliva concentration(Y)was Y=2.54×10-1X-1.09×10-2(n=202,r=0.8985,P0.01).The mean saliva/serum isoniazid concentration ratio was(24.89±3.90)%。Conculsion A significant positive correlation was found between isoniazid serum and saliva concentrations.The saliva sample may be a useful alternative to serum for therapeutic drug monitoring of isoniazid treatment.The isoniazid saliva /serum drug concentration ratio is not related to gender or age." @default.
- W2370760605 created "2016-06-24" @default.
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- W2370760605 date "2010-01-01" @default.
- W2370760605 modified "2023-10-08" @default.
- W2370760605 title "Determination of Serum and Salivary Isoniazid Concentrations by High Performance Liquid Chromatography and their Correlation in Saliva and in Serum in Patients with Epilepsy" @default.
- W2370760605 hasPublicationYear "2010" @default.
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