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- W2370774763 abstract "Objectives:Mechanical deformation of the dorsal root ganglion(DRG) and its nerve roots nearby are possible consequences of low back pain and sciatica,resulted from disc herniation,spinal stenosis, spinal injury or tumors.Multilevel lumbosacral radiculopathies are more common than single level radiculopathies in clinics,and patients exhibit multilevel nerve root compression and intervertebral foraminal stenosis.Thus,pain behaviors were examined in chronically compressed multiple DRG rats.Methods: On the basis of a previously estabalished chronic compression of DRG in the rat in the lab,the rat model of unilateral compression of multiple DRGs was used in the present study.The mechanical threshold of tactile allodynia and response score and frequency of cold allodynia were examined with von Frey filaments and acetone respectively.Results:Both ipsilateral and contralateral mechanical thresholds were significantly decreased in a unilateral compression of multlple DRG model(ipsilateral:4.0±0.4 g,P10~(-12);contralateral:6.0±0.5 g,P10~(-6),n =29).Furthermore,both ipsilateral and contralateral response scores to acetone were obviously increased after the chronic compression of multiple DRGs(ipsilateral: 2.1±0.1,P0.01;contralateral:1.6±0.2,P0.01,n = 16).Histological study showed obvious inflammation occurred in injured ipsilateral DRGs and their nerve root nearby.Conclusion;Both mechanical deformation and inflammatory irritation of nerve roots and DRGs are involved in the behaviors of mechanical and cold allodynia,accompanying with obvious delayed mirror pains in chronically compressed multiple DRG rats." @default.
- W2370774763 created "2016-06-24" @default.
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- W2370774763 date "2009-01-01" @default.
- W2370774763 modified "2023-09-24" @default.
- W2370774763 title "BEHAVIORS OF MECHANICAL AND COLD ALLODYNIA IN CHRONICALLY COMPRESSED MULTIPLE DRG RATS" @default.
- W2370774763 hasPublicationYear "2009" @default.
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