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- W2370785514 abstract "Objective To investigate the clinicopathological significance of the CyclinA and CyclinB 1 expression in laryngeal carcinogenesis.Methods The expression of CyclinB 1 and CyclinA was examined by immunohistochemistry method in nomal epithlia(20),dysplastic epithlia(40) and laryngeal cancers (60).Results ①Immunoreaction to Cyclin A and CyclinB 1 waslocalized in the nuclei of cells.②In normal epithlium,dysplastic squamous epithlium and in squamous cell carcinoma of the larynx,the positive immunostaining rate of CyclinA protein was 10.0%(2/20),30.0%(12/40) and 56.7%(34/60) respectively (P0.001),while CyclinB 1 protein was 15.0%(3/20),35.0%(14/40) and 63.3%(38/60)respectively(P0.001).③CyclinA and CyclinB 1 expression were observed more frequently in the tumors with lymph node metastasis (P0.05).④Conclusion CyclinA and CyclinB 1 could be an early molecular event in the carcinogenesis of larynx and play an important role in laryngeal tumors." @default.
- W2370785514 created "2016-06-24" @default.
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- W2370785514 date "2002-01-01" @default.
- W2370785514 modified "2023-09-25" @default.
- W2370785514 title "Clinicopathological significance of CyclinA and CyclinB_1 expression in laryngeal carcinogenesis" @default.
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