Matches in SemOpenAlex for { <https://semopenalex.org/work/W2370791355> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2370791355 abstract "Objective To know if Simvastatin could regulate matrix metalloproteinase-2,9 and matrix metalloproteinase tissue inhibitor-1,2 expression in mouse macrophages by experiment,to establish if Simvastatin could make arteriosclerotic plaques stable and prevent them from rupture in the way of regulating the expression of MMPs and TIMPs.Methods Culture mouse macrophages with different concentrations of Simvastatin,extract mRNA of the cells.By the method of RT-PCR to analyse matrix metalloproteinase-2,9 and matrix metalloproteinase tissue inhibitor-1,2 expression.Results The concentration of 5 μmol/mL of Simvastation affected the expression of matrix metalloproteinase 9 expression in large degree,the concentration of 50 μmol/mL and 100 μmol/mL inhibited matrix metalloproteinase-2,9 expression completely.Simvastatin down-regulated matrix metalloproteinase tissue inhibitor-1,2 in dose-dependent manner,that is,the higher concentration of Simvastatin,the more strongly the inhibitions were.Conclusion Simvastatin can make arteriosclerotic plaque stable by preventing them from rupture in the way of regulating the expression of MMPs and TIMPs,but the clinical dose of Simvastatin should not be too high" @default.
- W2370791355 created "2016-06-24" @default.
- W2370791355 creator A5000487179 @default.
- W2370791355 date "2002-01-01" @default.
- W2370791355 modified "2023-09-24" @default.
- W2370791355 title "Simvastatin regulates matrix metalloproteinase-2,9 and matrix metalloproteinase tissue inhibitor-1,2 expression in mouse macrophages" @default.
- W2370791355 hasPublicationYear "2002" @default.
- W2370791355 type Work @default.
- W2370791355 sameAs 2370791355 @default.
- W2370791355 citedByCount "0" @default.
- W2370791355 crossrefType "journal-article" @default.
- W2370791355 hasAuthorship W2370791355A5000487179 @default.
- W2370791355 hasConcept C104317684 @default.
- W2370791355 hasConcept C105580179 @default.
- W2370791355 hasConcept C106487976 @default.
- W2370791355 hasConcept C109523444 @default.
- W2370791355 hasConcept C126322002 @default.
- W2370791355 hasConcept C153911025 @default.
- W2370791355 hasConcept C185592680 @default.
- W2370791355 hasConcept C2775965246 @default.
- W2370791355 hasConcept C2776329913 @default.
- W2370791355 hasConcept C2991819120 @default.
- W2370791355 hasConcept C43617362 @default.
- W2370791355 hasConcept C55493867 @default.
- W2370791355 hasConcept C55728118 @default.
- W2370791355 hasConcept C71924100 @default.
- W2370791355 hasConcept C86803240 @default.
- W2370791355 hasConcept C95444343 @default.
- W2370791355 hasConcept C98274493 @default.
- W2370791355 hasConceptScore W2370791355C104317684 @default.
- W2370791355 hasConceptScore W2370791355C105580179 @default.
- W2370791355 hasConceptScore W2370791355C106487976 @default.
- W2370791355 hasConceptScore W2370791355C109523444 @default.
- W2370791355 hasConceptScore W2370791355C126322002 @default.
- W2370791355 hasConceptScore W2370791355C153911025 @default.
- W2370791355 hasConceptScore W2370791355C185592680 @default.
- W2370791355 hasConceptScore W2370791355C2775965246 @default.
- W2370791355 hasConceptScore W2370791355C2776329913 @default.
- W2370791355 hasConceptScore W2370791355C2991819120 @default.
- W2370791355 hasConceptScore W2370791355C43617362 @default.
- W2370791355 hasConceptScore W2370791355C55493867 @default.
- W2370791355 hasConceptScore W2370791355C55728118 @default.
- W2370791355 hasConceptScore W2370791355C71924100 @default.
- W2370791355 hasConceptScore W2370791355C86803240 @default.
- W2370791355 hasConceptScore W2370791355C95444343 @default.
- W2370791355 hasConceptScore W2370791355C98274493 @default.
- W2370791355 hasLocation W23707913551 @default.
- W2370791355 hasOpenAccess W2370791355 @default.
- W2370791355 hasPrimaryLocation W23707913551 @default.
- W2370791355 hasRelatedWork W1427310035 @default.
- W2370791355 hasRelatedWork W2027921103 @default.
- W2370791355 hasRelatedWork W2036091216 @default.
- W2370791355 hasRelatedWork W2039228516 @default.
- W2370791355 hasRelatedWork W2051172686 @default.
- W2370791355 hasRelatedWork W2073080880 @default.
- W2370791355 hasRelatedWork W2108192841 @default.
- W2370791355 hasRelatedWork W2136014491 @default.
- W2370791355 hasRelatedWork W2290133029 @default.
- W2370791355 hasRelatedWork W2292361936 @default.
- W2370791355 hasRelatedWork W2337639103 @default.
- W2370791355 hasRelatedWork W2390779578 @default.
- W2370791355 hasRelatedWork W251085771 @default.
- W2370791355 hasRelatedWork W2587544278 @default.
- W2370791355 hasRelatedWork W2977376710 @default.
- W2370791355 hasRelatedWork W3020267266 @default.
- W2370791355 hasRelatedWork W3104165838 @default.
- W2370791355 hasRelatedWork W2785169742 @default.
- W2370791355 hasRelatedWork W2827913703 @default.
- W2370791355 hasRelatedWork W3149298968 @default.
- W2370791355 isParatext "false" @default.
- W2370791355 isRetracted "false" @default.
- W2370791355 magId "2370791355" @default.
- W2370791355 workType "article" @default.