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- W2370791816 abstract "OBJECTIVE To synthesize a compound, which can specifically facilitate choroidal blood flow via increasing of nitric oxide(NO), for the treatment of age-related macular degeneration(AMD). METHODS A pair of stereoisomers was prepared by seven steps from 3,4,5-trimethoxybenzaldehyde and their structures were confirmed by IR,~ 1 H-NMR,MS and elemental analysis. The production of nitric oxide in vitro and the blood flow of rabbit eye tissue were investigated. RESULTS The target compounds were prepared in high yields. Trans isomer ZX-5 released significant amount of NO and specifically increased the choroidal blood flow,while cis isomer ZX-4 did not show these activities.CONCLUSION ZX-5 is a promising compound in the prevention/treatment of AMD in the elder." @default.
- W2370791816 created "2016-06-24" @default.
- W2370791816 creator A5046899903 @default.
- W2370791816 date "2006-01-01" @default.
- W2370791816 modified "2023-09-25" @default.
- W2370791816 title "Studies on Synthesis and Biological Activity of Novel Anti-AMD Agent" @default.
- W2370791816 hasPublicationYear "2006" @default.
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