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- W2370792332 abstract "Objective To determine if histopathological factors of primary penile squamous cell carcinoma can predict the risk of the development of regional lymph node metastasis.Methods The clinical records of 72 consecutive patients with squamous cell carcinoma of the penis were analyzed retrospectively.Of the 72 patients,58 underwent bilateral inguinal lymph node dissection;among them 9 also had unilateral or bilateral pelvic lymph node dissection.Primary lesions were re-evaluated according to the recently revised standards,including 2004 WHO histopathological classification and grading system and 2002 UICC TNM staging system.Variables included histopathological classification,histological grade,pathological tumor stage,depth of invasion,presence or absence of vascular invasion,and number and position of metastatic lymph nodes.Results No regional lymph node metastasis was found in 8 cases of verrucous carcinoma.All 5 cases(100.0%) of basaloid squamous cell carcinoma developed lymph node metastases.Regional lymph metastases occurred in 3(33.3%) of 9 cases of warty squamous cell carcinoma and in 15(30.0%) of 50 cases of typical squamous cell carcinoma.The differences among these groups were significant(P=(0.002)).Metastases occurred in 15.0%(6/40) of cases of T_a or T_1 stage,as compared with 53.1%(17/32) of cases of T_2 or T_3 stage(P0.001).Metastases occurred in 20.8%(5/24) of G_1,32.3%(10/31) of G_2 and 47.1%(8/17) of G_3 cases,with no significant difference among them (P0.05).The mean depth of invasion among patients with lymph node metastases was 9.3mm,as compared with that of only 2.7 mm among those without(P0.001).Conclusions The histopathological classification,tumor stage,and depth of invasion of primary lesions are significant predictors for regional lymph node metastasis of penile squamous cell carcinoma.Combination of these predictors can be used to guide clinical practice." @default.
- W2370792332 created "2016-06-24" @default.
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- W2370792332 date "2006-01-01" @default.
- W2370792332 modified "2023-09-25" @default.
- W2370792332 title "Predicting regional lymph node metastasis in patients with penile squamous cell carcinoma:the role of histopathological classification,tumor stage and depth of invasion" @default.
- W2370792332 hasPublicationYear "2006" @default.
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